期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 15, 页码 2465-2468出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-012-1043-0
关键词
PGC-1 alpha; Mitochondria; Dopaminergic neurons; Transgenic animal; Adenovirus; Parkinson's disease
资金
- Academy of Finland
- Sigrid Juselius Foundation
- Liv och Halsa
- Finnish Parkinson Foundation
- Magnus Ehrnrooth
- Minerva Foundation
Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1 alpha gene-deleted mice, suggesting that PGC-1 alpha is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1 alpha overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1 alpha in cell stress and in control of neuronal homeostasis?.
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