期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 13, 页码 2161-2176出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0710-x
关键词
Host defence peptide; Antimicrobial; Immunomodulatory; Immunity; Infection; Therapeutics; Chemoattractant; Inflammation
资金
- Canadian Institutes for Health Research (CIHR)
- Canadian Cystic Fibrosis Foundation (CCFF)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
With the rapid rise in the emergence of bacterial strains resistant to multiple classes of antimicrobial agents, there is an urgent need to develop novel antimicrobial therapies to combat these pathogens. Cationic host defence peptides (HDPs) and synthetic derivatives termed innate defence regulators (IDRs) represent a promising alternative approach in the treatment of microbial-related diseases. Cationic HDPs (also termed antimicrobial peptides) have emerged from their origins as nature's antibiotics and are widely distributed in organisms from insects to plants to mammals and non-mammalian vertebrates. Although their original and primary function was proposed to be direct antimicrobial activity against bacteria, fungi, parasites and/or viruses, cationic HDPs are becoming increasingly recognized as multifunctional mediators, with both antimicrobial activity and diverse immunomodulatory properties. Here we provide an overview of the antimicrobial and immunomodulatory activities of cationic HDPs, and discuss their potential application as beneficial therapeutics in overcoming infectious diseases.
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