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Kevin Ramirez et al.
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Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
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T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
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The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
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NK cell-activating receptors require PKC-θ for sustained signaling, transcriptional activation, and IFN-γ secretion
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Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-κB and MAPK activation to selectively control cytokine production
Olaf Gross et al.
BLOOD (2008)
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TGF-β utilizes SMAD3 to inhibit CD16-mediated IFN-γ production and antibody-dependent cellular cytotoxicity in human NK cells
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T-bet plays a key role in NK-Mediated control of melanoma metastatic disease
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Natural killer cells from protein kinase C θ-/- mice stimulated with interleukin-12 are deficient in production of interferon-γ
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Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
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Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity
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A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
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The kiss of death: interrupted by NK-cell close encounters of another kind
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T-bet is required for optimal proinflammatory CD4+ T-cell trafficking
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NFAT proteins: Key regulators of T-cell development and function
F Macian
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IFN regulatory factor-2 deficiency revealed a novel checkpoint critical for the generation of peripheral NK cells
S Taki et al.
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T-bet regulates the terminal maturation and homeostasis of NK and Vα14i NKT cells
MJ Townsend et al.
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Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
A Martín-Fontecha et al.
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Recent developments in the transcriptional regulation of cytolytic effector cells
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Assembling a gene regulatory network for specification of the B cell fate
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Bcl11a is essential for normal lymphoid development
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GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells
SI Samson et al.
IMMUNITY (2003)
Coordinated and distinct roles for IFN-αβ, IL-12, and IL-15 regulation of NK cell responses to viral infection
KB Nguyen et al.
JOURNAL OF IMMUNOLOGY (2002)
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
S Mandala et al.
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Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
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TOX: an HMG box protein implicated in the regulation of thymocyte selection
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Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells
F Colucci et al.
BLOOD (2001)
Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2
T Ikawa et al.
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Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice
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Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells
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Interferon α/β-mediated inhibition and promotion of interferon γ:: STATI resolves a paradox
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A novel transcription factor, T-bet, directs Th1 lineage commitment
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