期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 18, 页码 2977-3006出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0683-9
关键词
ATM kinase; DNA damage response; Signaling; Carcinogenesis
资金
- National Health and Medical Research Council (NHMRC)
- Australian Research Council (ARC)
- Cancer Council Queensland (CCQ)
ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.
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