期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 69, 期 12, 页码 1947-1965出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0905-1
关键词
Amylin; Amylin receptor; Satiation; Adiposity; Histamine; Leptin; Estradiol
资金
- Swiss National Science Foundation
- Zurich Center of Integrative Human Physiology
- Novartis Foundation
- Ciba-Geigy Foundation
- Olga Mayenfisch Foundation
- Vontobel Foundation
Amylin is an important control of nutrient fluxes because it reduces energy intake, modulates nutrient utilization by inhibiting postprandial glucagon secretion, and increases energy disposal by preventing compensatory decreases of energy expenditure in weight-reduced individuals. The best investigated function of amylin which is cosecreted with insulin is to reduce eating by promoting meal-ending satiation. This effect is thought to be mediated by a stimulation of specific amylin receptors in the area postrema. Secondary brain sites to mediate amylin action include the nucleus of the solitary tract and the lateral parabrachial nucleus, which convey the neural signal to the lateral hypothalamic area and other hypothalamic nuclei. Amylin may also signal adiposity because plasma levels of amylin are increased in adiposity and because higher amylin concentrations in the brain result in reduced body weight gain and adiposity, while amylin receptor antagonists increase body adiposity. The central mechanisms involved in amylin's effect on energy expenditure are much less known. A series of recent experiments in animals and humans indicate that amylin is a promising option for anti-obesity therapy especially in combination with other hormones. The most extensive dataset is available for the combination therapy of amylin and leptin. Ongoing research focuses on the mechanisms of these interactions.
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