期刊
CYTOGENETIC AND GENOME RESEARCH
卷 99, 期 1-4, 页码 25-29出版社
KARGER
DOI: 10.1159/000071571
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资金
- NICHD NIH HHS [HD16659] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R37HD016659, R01HD016659] Funding Source: NIH RePORTER
Mutations in the DNMT3B DNA methyltransferase gene cause the ICF immunodeficiency syndrome. The targets of this DNA methyltransferase are CpG-rich heterochromatic regions, including pericentromeric satellites and the inactive X chromosome. The abnormal hypomethylation in ICF cells provides an important model system for determining the relationships between replication time, CpG island methylation, chromatin structure, and gene silencing in X chromosome inactivation. Copyright (C) 2002 S. Karger AG, Basel.
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