期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 21, 页码 3469-3478出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0798-z
关键词
NK cell receptor; Ly49; LILRB/PIR-B; MHC; Notch; Cis interaction; Trans interaction; NK cell education
资金
- Swiss National Science Foundation
- Oncosuissse
- National Institutes of Health [AI47990]
Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.
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