期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 16, 页码 2655-2666出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-011-0664-z
关键词
Nervous vascular parallels; Synapse; Neurexin; Neuroligin
资金
- Italian Association for Cancer Research (AIRC)
- Regione Piemonte
- CRT Foundation
- Italian Ministry of Health
The scientific interest in the family of the so-called nervous vascular parallels has been growing steadily for the past 15 years, either by addition of new members to the group or, lately, by deepening the analysis of established concepts and mediators. Proteins governing both neurons and vascular cells are known to be involved in events such as cell fate determination and migration/guidance but not in the last and apparently most complex step of nervous system development, the formation and maturation of synapses. Hence, the recent addition to this family of the specific synaptic proteins, Neurexin and Neuroligin, is a double innovation. The two proteins, which were thought to be simple adhesive links between the pre- and post-synaptic sides of chemical synapses, are in fact extremely complex and modulate the most subtle synaptic activities. We will discuss the relevant data and the intriguing challenge of transferring synaptic activities to vascular functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据