期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 2, 页码 205-218出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0527-z
关键词
Phosphate sensing; Phosphate homeostasis; Bone mineralization; Signaling; SLC20a1; SLC20a2
资金
- INSERM
- ANR [PHYSIOPATH ANR-07-PHYSIO-017-01]
- La Fondation pour la Recherche Medicale (AAP Vieillissement osteoarticulaire'')
- BIOREGOS
- Region des Pays de la Loire
- INSERM/Region des Pays de la Loire
- La Fondation pour la Recherche Medicale
Although considerable advances in our understanding of the mechanisms of phosphate homeostasis and skeleton mineralization have recently been made, little is known about the initial events involving the detection of changes in the phosphate serum concentrations and the subsequent downstream regulation cascade. Recent data has strengthened a long-established hypothesis that a phosphate-sensing mechanism may be present in various organs. Such a phosphate sensor would detect changes in serum or local phosphate concentration and would inform the body, the local environment, or the individual cell. This suggests that phosphate in itself could represent a signal regulating multiple factors necessary for diverse biological processes such as bone or vascular calcification. This review summarizes findings supporting the possibility that phosphate represents a signaling molecule, particularly in bone and cartilage, but also in other tissues. The involvement of various signaling pathways (ERK1/2), transcription factors (Fra-1, Runx2) and phosphate transporters (PiT1, PiT2) is discussed.
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