期刊
BIOELECTROCHEMISTRY
卷 55, 期 1-2, 页码 71-74出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S1567-5394(01)00164-5
关键词
ion channel; erythrocyte; patch-clamp; prostaglandin E-2; clot formation
Using the patch-clamp technique, two different ion channels have been characterized further in the human red blood cell (RBC) membrane. We demonstrate that the non-selective cation channel (NSC) is permeable to Ca2+ and can be activated by prostaglandin E-2 (PGE(2)). Therefore, the physiological role of this channel could be, together with the Ca2+-activated K channel, the participation in the process of blood clot formation. We give also evidence that another channel in the RBC membrane, so far assumed to be a small conductance anion channel, is more likely to be a proton or a hydroxyl ion channel. (C) 2002 Elsevier Science B.V All rights reserved.
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