期刊
ARTHRITIS RESEARCH & THERAPY
卷 4, 期 -, 页码 S69-S78出版社
BIOMED CENTRAL LTD
DOI: 10.1186/ar563
关键词
adhesion; cations; extracellular matrix; integrin; structure
类别
资金
- Wellcome Trust
Integrin receptors transduce bidirectional signals between extracellular adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural basis of integrin signalling is unknown, but the recent publication of the first crystal structure of the extracellular domain of integrin alpha V beta 3 has provided a number of insights. In this review, previous structure-function analyses of integrins that have employed biochemical and molecular biological approaches are placed in the context of the crystal structure, and novel routes to the development of integrin antagonists are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据