期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 10, 页码 1589-1597出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0285-y
关键词
Mitochondria; Bcl-2 family; Cell death; Apoptosis; Caspase-independent cell death; Mitochondrial outer membrane permeabilization; Cancer; BH3 mimetics
资金
- Association pour la Recherche sur le Cancer (ARC), l'Agence Nationale de la Recherche [ANR-09-JCJC-0003-01]
- la Fondation de France and Region Provence-Alpes-Cote-d'Azur
- INSERM-CHU de Nice
Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because mitochondria-enriched fractions were found to be necessary for activation of death proteases, the caspases, in a cell-free model of apoptotic cell death. Mitochondrial involvement in apoptosis was subsequently shown to be regulated by Bcl-2, a protein that was known to contribute to cancer in specific circumstances. The important role of mitochondria in promoting caspase activation has therefore been a major focus of apoptosis research; however, it is also clear that mitochondria contribute to cell death by caspase-independent mechanisms. In this review, we will highlight recent findings and discuss the mechanism underlying the mitochondrial control of apoptosis and caspase-independent cell death.
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