期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 8, 页码 1255-1264出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0252-7
关键词
Acetylation; Metabolism; Migration; Neurodegenerative disorders; Cancer; HDAC; Sirtuins
资金
- F. R. S.-F. N. R. S., TELEVIE
- Belgian Federation against cancer
- Concerted Research Action Program [04/09-323]
- Inter-University Attraction
- Centre Anti-Cancereux
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
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