期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 68, 期 2, 页码 315-323出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0458-8
关键词
Astakine; Circadian rhythm; Cytokine; Hematopoiesis; Innate immunity; Prokineticin
资金
- Swedish Science Research Council
- Formas
Invertebrate circulating hemocytes are key players in the innate immune defense and their continuous renewal from hematopoietic tissues is tightly regulated in crustaceans by astakine, a new family of cytokines sharing a prokineticin (PROK) domain. In vertebrates, brain PROKs function as transmitters of circadian rhythms and we present evidence that hemocyte release from hematopoietic tissues in crayfish is under circadian regulation, a direct result of rhythmic expression of astakine. We demonstrate that the observed variation in astakine expression has an impact on innate immunity assessed as susceptibility to a pathogenic Pseudomonas species. These findings enlighten the importance of comparing immune responses at fixed times not to neglect circadian regulation of innate immunity. Moreover, our results entail an evolutionary conserved function for prokineticins as mediators of circadian rhythm, and for the first time show a role for this domain in circadian regulation of hematopoiesis that may have implications also in vertebrates.
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