期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 18, 页码 3089-3099出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-010-0403-x
关键词
bHLH genes; Neurosensory development; Neurosensory evolution; Ear development; Hair cells
资金
- NIH-NIDCD [R01-DC005590]
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R21DC011397, R01DC005590] Funding Source: NIH RePORTER
In mouse ear development, two bHLH genes, Atoh1 and Neurog1, are essential for hair cell and sensory neuron differentiation. Evolution converted the original simple atonal-dependent neurosensory cell formation program of diploblasts into the derived developmental program of vertebrates that generates two neurosensory cell types, the sensory neuron and the sensory hair cell. This transformation was achieved through gene multiplication in ancestral triploblasts resulting in the expansion of the atonal bHLH gene family. Novel genes of the Neurogenin and NeuroD families are upregulated prior to the expression of Atoh1. Recent data suggest that NeuroD and Neurogenin were lost or their function in neuronal specification reduced in flies, thus changing our perception of the evolution of these genes. This sequence of expression changes was accompanied by modification of the E-box binding sites of these genes to regulate different downstream genes and to form inhibitory loops among each other, thus fine-tuning expression transitions.
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