期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 7, 页码 1025-1048出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0213-1
关键词
CAS; BCAR1; NEDD9; Scaffold; Cancer; Invasion; Metastasis; Mitosis
资金
- NIH [R01 CA63366, R01 CA113342, T32 CA009035, CA06927]
- NATIONAL CANCER INSTITUTE [T32CA009035, R01CA113342, P30CA006927, R01CA063366] Funding Source: NIH RePORTER
Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor prognosis and increased metastasis in cancer, as well as resistance to first-line chemotherapeutics in multiple tumor types including breast and lung cancers, glioblastoma, and melanoma. Further, CAS proteins have also been linked to additional pathological conditions including inflammatory disorders, Alzheimer's and Parkinson's disease, as well as developmental defects. This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.
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