期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 23, 页码 3711-3725出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0104-5
关键词
Phanerochaete chrysosporium; Glutathione S-transferase; Etherase; Omega class GST; Ure2p; GTT
资金
- ANR [ANR-06-BLAN-0386]
- Agence Nationale de la Recherche (ANR) [ANR-06-BLAN-0386] Funding Source: Agence Nationale de la Recherche (ANR)
The recent release of several basidiomycete genome sequences allows an improvement of the classification of fungal glutathione S-transferases (GSTs). GSTs are well-known detoxification enzymes which can catalyze the conjugation of glutathione to non-polar compounds that contain an electrophilic carbon, nitrogen, or sulfur atom. Following this mechanism, they are able to metabolize drugs, pesticides, and many other xenobiotics and peroxides. A genomic and phylogenetic analysis of GST classes in various sequenced fungi-zygomycetes, ascomycetes, and basidiomycetes-revealed some particularities in GST distribution, in comparison with previous analyses with ascomycetes only. By focusing essentially on the wood-degrading basidiomycete Phanerochaete chrysosporium, this analysis highlighted a new fungal GST class named GTE, which is related to bacterial etherases, and two new subclasses of the omega class GSTs. Moreover, our phylogenetic analysis suggests a relationship between the saprophytic behavior of some fungi and the number and distribution of some GST isoforms within specific classes.
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