期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 9, 页码 1507-1517出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-8704-7
关键词
Enoyl-acyl carrier protein reductase; fatty acid biosynthesis; Fatty acid synthesis II; triclosan; short-chain dehydrogenase reductase; medium-chain dehydrogenase reductase
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI015650] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI015650-32, R01 AI015650] Funding Source: Medline
The enoyl-acyl carrier protein reductase (ENR) is the last enzyme in the fatty acid elongation cycle. Unlike most enzymes in this essential pathway, ENR displays an unusual diversity among organisms. The growing interest in ENRs is mainly due to the fact that a variety of both synthetic and natural antibacterial compounds are shown to specifically target their activity. The primary anti-tuberculosis drug, isoniazid, and the broadly used antibacterial compound, triclosan, both target this enzyme. In this review, we discuss the diversity of ENRs, and their inhibitors in the light of current research progress.
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