期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 15, 页码 2503-2524出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0034-2
关键词
Replicative senescence; Postmitotic cell; Aging; Fibroblast; Lysosomes; Mitochondria; Senescence-associated heterochromatin foci (SAHF); Telomere dysfunction-induced focus (TIF)
资金
- Korea Science and Engineering Foundation [M10756040001-08N5604-00110]
- Korea Research Foundation [KRF-2007-314-C00229]
- National Research Foundation of Korea [2007-314-C00229, 과C6A2602, 핵06A3102, 2007-2006431] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed. Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据