期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 24, 期 1, 页码 68-77出版社
JOHN WILEY & SONS INC
DOI: 10.1002/hed.10000
关键词
swallowing; dysphagia; RADPLAT; cisplatin; video-fluorography
资金
- NCI NIH HHS [P01 CA 40007] Funding Source: Medline
- NIDCR NIH HHS [P50 DE/CA 11921] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P01CA040007] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [P50DE011921] Funding Source: NIH RePORTER
Objective. RADPLAT (concurrent selective supra-dose intraarterial cisplatin and external-beam irradiation) delivers extraordinarily high cisplatin concentration to head and neck structures. This study was designed to quantify and compare RADPLAT and systemic chemoradiation treatment effects on swallowing and speech. Methods. Videofluorographic swallowing studies and articulation testing of 14 head and neck cancer patients treated with RADPLAT were compared with 16 treated with systemic chemoradiation 1 month after treatment. Results. RADPLAT and systemic chemoradiation patients did not differ significantly on most swallow outcome measures, and there was significantly less aspiration on 1 and 3 mL liquid for RADPLAT individuals. Speech function was comparable except for RADPLAT's significantly worse /s, z/ productions. Conclusions. Increased concentration of cisplatin to the head and neck did not result in generally reduced swallowing or articulatory function. (C) 2002 John Wiley & Sons, Inc.
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