期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 67, 期 5, 页码 715-726出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0186-0
关键词
Cell penetrating peptides; Nucleic acids delivery; Drug delivery
资金
- AFM (Association Francaise contre les Myopathies)
- ANR (Agence Nationale de la Recherche)
- LNFCC (Ligue Nationale de Lutte contre le Cancer)
- MRC-Technology
- Action Duchenne
- MRC [MC_U105178803] Funding Source: UKRI
- Medical Research Council [MC_U105178803] Funding Source: researchfish
Crossing biological barriers represents a major limitation for clinical applications of biomolecules such as nucleic acids, peptides or proteins. Cell penetrating peptides (CPP), also named protein transduction domains, comprise short and usually basic amino acids-rich peptides originating from proteins able to cross biological barriers, such as the viral Tat protein, or are rationally designed. They have emerged as a new class of non-viral vectors allowing the delivery of various biomolecules across biological barriers from low molecular weight drugs to nanosized particles. Encouraging data with CPP-conjugated oligonucleotides have been obtained both in vitro and in vivo in animal models of diseases such as Duchenne muscular dystrophy. Whether CPP-cargo conjugates enter cells by direct translocation across the plasma membrane or by endocytosis remains controversial. In many instances, however, endosomal escape appears as a major limitation of this new delivery strategy.
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