期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 14, 页码 2249-2261出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-009-0015-5
关键词
DNA hypomethylation; G-specific hypomethylation; Cancer; Atherosclerosis; Alzheimer's disease; Psychiatric disorders
The pathogenesis of any given human disease is a complex multifactorial process characterized by many biologically significant and interdependent alterations. One of these changes, specific to a wide range of human pathologies, is DNA hypomethylation. DNA hypomethylation signifies one of the major DNA methylation states that refers to a relative decrease from the normal methylation level. It is clear that disease by itself can induce hypomethylation of DNA; however, a decrease in DNA methylation can also have an impact on the predisposition to pathological states and disease development. This review presents evidence suggesting the involvement of DNA hypomethylation in the pathogenesis of several major human pathologies, including cancer, atherosclerosis, Alzheimer's disease, and psychiatric disorders.
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