期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 123, 期 2-3, 页码 231-242出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0047-6374(01)00348-7
关键词
centenarian; oldest old; longevity; genetics; longevity-enabling gene; demographic selection
资金
- NIA NIH HHS [1R01AG18721, 1R21AG16916] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R21AG016916, R01AG018721] Funding Source: NIH RePORTER
Centenarians disprove the ageist myth the older you get, the sicker you get: they live 90-95%, of their very long lives in excellent health, only to experience illnesses in the very last few years of their lives, Thus, it appears that in order to live to 100. one must age relatively slowly and markedly delay and/or escape age-associated diseases. How they achieve such a survival advantage is still a mystery though it is becoming increasingly clear that a substantial genetic advantage plays a role in their ability to live 20-25 years beyond average life expectancy. Current genetic studies of centenarian sibships may yield the identity of some of these genes in the near future. Identifying such genes may yield new information about how people age differently and what modulates differences in susceptibilities to various diseases associated with aging. (C) 2002 Published by Elsevier Science Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据