期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 14, 页码 2215-2231出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8060-z
关键词
ion channels; phosphorylation; channel kinetics; alternative splicing; trafficking; and neural plasticity
The ion channel milieu present in a neuron in large part determines the inherent excitability of a given cell and is responsible for the translation of sensory transduction and synaptic input to axonal output. Intrinsic excitability is a dynamic process subject to multiple levels of regulation from channel gene expression to post-translational modifications that influence channel activity. The goal of this review is to provide an overview of some of the mechanisms by which channels can be modified in order to influence neuronal output. We focus on four levels of regulation: channel gene transcription, alternative splicing of channel transcripts, post-translational modifications that alter channel kinetics (phosphorylation), and subcellular localization and trafficking of channel proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据