期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 18, 页码 2801-2813出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8351-4
关键词
docking; exocytosis; Rab3; Rab27; Rab effector; rabphilin; secretory vesicle; synaptotagmin-like protein
资金
- Ministry of Education, Culture, Sports, and Technology of Japan [18022048, 18050038, 18057026, 18207015, 19044003]
- Naito Foundation, the Takeda Science Foundation, the Gushinkai Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [18022048, 19044003, 18057026, 18050038, 18207015, 20113006] Funding Source: KAKEN
Secretion is a fundamental biological activity of all eukaryotic cells by which they release certain substances in the extracellular space. It is considered a specialized mode of membrane trafficking that is achieved by docking and fusion of secretory vesicles to the plasma membrane (i.e., exocytosis). Secretory vesicle traffic is thought to be regulated by a family of Rab small GTPases, which are regulators of membrane traffic that are common to all eukaryotic cells. Classically, mammalian Rab3 subfamily members were thought to be critical regulators of secretory vesicle exocytosis in neurons and endocrine cells, but recent genetic and proteomic studies indicate that Rab3 is not the sole Rab isoform that regulates secretory vesicle traffic. Rather, additional Rab isoforms, especially Rab27 subfamily members, are required for this process. In this article I review the current literature on the function of Rab isoforms and their effectors in regulated secretory vesicle traffic.
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