期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 5, 页码 672-686出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-7484-1
关键词
thrombospondin; extracellular protein structure; cartilage oligomeric matrix protein; calcium
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL049081, R01HL054462] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL054462-13, HL07899, HL49081, HL54462, R01 HL054462] Funding Source: Medline
Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review).
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