期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 3, 页码 370-374出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8552-x
关键词
Rac1; Rho GTPases; proliferation; cytoskeleton; survival
资金
- National Institutes of Health
Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to regulate multiple signaling pathways that control cytoskeleton organization, transcription, and cell proliferation. Deregulated expression or activation patterns of Rac1 can result in aberrant cell signaling and numerous pathological conditions. Here, we highlight the physiological functions and signaling mechanisms of Rac1 and their relevance to disease.
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