期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 21, 页码 3383-3398出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8497-0
关键词
Virus restriction factors; retroviral receptors; Env-receptor interactions; murine ERV classification
资金
- Intramural NIH HHS [Z99 AI999999, Z01 AI000300-26] Funding Source: Medline
Up to 10% of the mouse genome is comprised of endogenous retrovirus (ERV) sequences, and most represent the remains of ancient germ line infections. Our knowledge of the three distinct classes of ERVs is inversely correlated with their copy number, and their characterization has benefited from the availability of divergent wild mouse species and subspecies, and from ongoing analysis of the Mus genome sequence. In contrast to human ERVs, which are nearly all extinct, active mouse ERVs can still be found in all three ERV classes. The distribution and diversity of ERVs has been shaped by host-virus interactions over the course of evolution, but ERVs have also been pivotal in shaping the mouse genome by altering host genes through insertional mutagenesis, by adding novel regulatory and coding sequences, and by their co-option by host cells as retroviral resistance genes. We review mechanisms by which an adaptive coexistence has evolved. (Part of a Multiauthor Review).
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