期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 8, 页码 1419-1433出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8605-1
关键词
Cross-talk; histone; lysine; methylation; ubiquitination; gene expression; DNA repair
资金
- American Heart Association [0635008N, 0710187Z]
- American Cancer Society [06-52]
- Mallinckrodt Foundation award
- Southern Illinois University
Methylation of lysine residues of histones is associated with functionally distinct regions of chromatin, and, therefore, is an important epigenetic mark. Over the past few years, several enzymes that catalyze this covalent modification on different lysine residues of histones have been discovered. Intriguingly, histone lysine methylation has also been shown to be cross-regulated by histone ubiquitination or the enzymes that catalyze this modification. These covalent modifications and their cross-talks play important roles in regulation of gene expression, heterochromatin formation, genome stability, and cancer. Thus, there has been a very rapid progress within past several years towards elucidating the molecular basis of histone lysine methylation and ubiquitination, and their aberrations in human diseases. Here, we discuss these covalent modifications with their cross-regulation and roles in controlling gene expression and stability.
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