期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 13, 页码 2056-2068出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7586-4
关键词
metalloprotease; disintegrin; proteolysis; signaling; Notch; Delta; ligand
资金
- NIGMS NIH HHS [GM 065528, R01 GM065528-01A2, R01 GM065528, R01 GM065528-02, R01 GM065528-03, R01 GM065528-04] Funding Source: Medline
ADAM metalloproteases play important roles in development and disease. One of the key functions of ADAMs is the proteolytic processing of Notch receptors and their ligands. ADAM-mediated cleavage of Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway. Recent reports indicate that the transmembrane Notch ligands also undergo ADAM-mediated processing in cultured cells and in vivo. The proteolytic processing of Notch ligands modulates the strength and duration of Notch signals, leads to generation of soluble intracellular domains of the ligands, and may support a bi-directional signaling between cells.
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