期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 7-8, 页码 1220-1236出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7565-9
关键词
serine proteases; enzyme catalysis; thrombin; allostery
资金
- NHLBI NIH HHS [HL 49413, HL 73813, HL 58141] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL049413, R01HL058141, R01HL073813, R29HL049413] Funding Source: NIH RePORTER
Serine peptidases play key roles in human health and disease and their biochemical properties shaped the molecular evolution of these processes. Of known proteolytic enzymes, the serine peptidase family is the major cornerstone of the vertebrate degradome. We describe the known diversity of serine peptidases with respect to structure and function. Particular emphasis is placed on the S1 peptidase family, the trypsins, which underwent the most predominant genetic expansion yielding the enzymes responsible for vital processes in man such as digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis and immunity.
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