期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 3, 页码 447-459出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8463-x
关键词
Prolactin inducible protein; antisperm antibody; tumor progression and metastasis; apoptosis; CD4-T cell receptor; fertilization
资金
- Council of Scientific and Industrial Research (CSIR)
- DST
Prolactin inducible protein (PIP) is a 17- kDa single polypeptide chain, known by various names due to its versatile nature and function in human reproductive and immunological systems. It is expressed in several exocrine tissues such as the lacrimal, salivary, and sweat glands. Its expression is up regulated by prolactin and androgens, and estrogens down regulate it. Due to its over-expression in metastatic breast and prostate cancer, presently PIP is considered as a prognostic biomarker. Moreover, its aspartyl-proteinase nature suggests its role in tumor progression. PIP has unique features because it is small in size and plays multiple important functions. Its ability to bind potentially with CD4-T cell receptor, immunoglobulin G (IgG), actin, zinc alpha 2-glycoprotein (ZAG), fibronectin and enamel pellicle, reveals its important biological functions. This is the first comprehensive review on the structure and functional analysis of PIP and its clinical applications.
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