期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 66, 期 3, 页码 407-422出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8303-z
关键词
Chromatin; methylation; demethylation; histone; epigenetics
资金
- Structural Genomics Consortium [1097737]
- Canadian Foundation for Innovation, Genome Canada
- Ontario Ministry for Research and Innovation, Merck and Co
- Swedish Foundation
- Wellcome Trust
Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals.
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