期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 13, 页码 1957-1976出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-7578-4
关键词
phagocytosis; signalling; receptors; actin; G proteins; membrane; pathogens
资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council Funding Source: Medline
Phagocytosis is a highly conserved, complex process that has evolved to counter the constant threat posed by pathogens, effete cells and debris. Classically defined as a mechanism for internalising and destroying particles greater than 0.5 mu m in size, it is a receptor-mediated, actin-driven process. The best-studied phagocytic receptors are the opsono-receptors, Fc gamma R and CR3. Phagocytic uptake involves actin dynamics including polymerisation, bundling, contraction, severing and depolymerisation of actin filaments. Recent evidence points to the importance of membrane remodelling during phagocytosis, both in terms of changes in lipid composition and delivery of new membrane to the sites of particle binding. Here we review the molecular mechanisms of phagocytic uptake and some of the strategies developed by microbial pathogens to manipulate this process.
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