期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 65, 期 19, 页码 3028-3039出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-008-8125-z
关键词
protein-lipid interactions; GPCR; channel; pore; Bcl-2; colicin; alamethicin; melittin
资金
- Vaincre la Mucoviscidose [TG 501]
- Association pour la Recherche sur le Cancer [3100]
- Agence Nationale de Recherche (MEMBAX, PolyQ and TRANSPEP)
Biological membranes are highly dynamic supramolecular arrangements of lipids and proteins, which fulfill key cellular functions. Relatively few high-resolution membrane protein structures are known to date, although during recent years the structural databases have expanded at an accelerated pace. In some instances the structures of reaction intermediates provide a stroboscopic view on the conformational changes involved in protein function. Other biophysical approaches add dynamic aspects and allow one to investigate the interactions with the lipid bilayers. Membrane-active peptides fulfill many important functions in nature as they act as antimicrobials, channels, transporters or hormones, and their studies have much increased our understanding of polypeptide-membrane interactions. Interestingly several proteins have been identified that interact with the membrane as loose arrays of domains. Such conformations easily escape classical high-resolution structural analysis and the lessons learned from peptides may therefore be instructive for our understanding of the functioning of such membrane proteins.
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