期刊
CELLULAR AND MOLECULAR BIOENGINEERING
卷 8, 期 1, 页码 96-105出版社
SPRINGER
DOI: 10.1007/s12195-014-0368-1
关键词
Mechanobiology; Forster resonance energy transfer; Biosensors; Mechanotransduction; Fluorescence lifetime imaging microscopy
资金
- German Research Council (DFG) [EN GR3399-2-1]
- Collaborative Research Center [SFB63]
- Paul Gerson Unna Research Group of the Max Planck Society (MPG)
The ability of cells to sense and respond to mechanical forces is central to a wide range of biological processes and plays an important role in numerous pathologies. The molecular mechanisms underlying cellular mechanotransduction, however, have remained largely elusive because suitable methods to investigate subcellular force propagation were missing. Here, we review recent advances in the development of biosensors that allow molecular force measurements. We describe the underlying principle of currently available techniques and propose a strategy to systematically evaluate new Forster resonance energy transfer (FRET)-based biosensors.
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