期刊
IEEE TRANSACTIONS ON MEDICAL IMAGING
卷 22, 期 11, 页码 1358-1368出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TMI.2003.819293
关键词
brain modeling; brain shift; image-guided neurosurgery; image registration; intraoperative ultrasound
类别
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS033900] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01-NS33900] Funding Source: Medline
Brain shift during open cranial surgery presents a challenge for maintaining registration with image-guidance systems. Ultrasound (US) is a convenient intraoperative imaging modality that may be a useful tool in detecting tissue shift and updating preoperative images based on intraoperative measurements of brain deformation. We have quantitatively evaluated the ability of spatially tracked freehand US to detect displacement of implanted markers in a series of three in vivo porcine experiments, where both US and computed tomography (CT) image acquisitions were obtained before and after deforming the brain. Marker displacements ranged from 0.5 to 8.5 mm. Comparisons between CT and US measurements showed a mean target localization error of 1.5 mm, and a mean vector error for displacement of 1.1 mm. Mean error in the magnitude of displacement was 0.6 mm. For ne of the animals studied, the US data was used in conjunction with a biomechanical model to nonrigidly re-register a baseline CT to the deformed brain. The mean error between the actual and deformed CT's was found to be on average 1.2 and 1.9 mm at the marker locations depending on the extent of the deformation induced. These findings indicate the potential accuracy in coregistered freehand US displacement tracking in brain tissue and suggest that the resulting information can be used to drive a modeling re-registration strategy to comparable levels of agreement.
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