期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 28, 期 11, 页码 576-580出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2003.09.007
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资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068631, R01GM025326] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01-GM25326, 1R01GM68631-01] Funding Source: Medline
A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.
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