期刊
MECHANISMS OF DEVELOPMENT
卷 120, 期 11, 页码 1283-1296出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2003.07.003
关键词
phosphatidylinositol 3-kinase; target of rapamycin; cell growth; autophagy; morphogenesis; spindle orientation; Drosophila
资金
- NIGMS NIH HHS [R01 GM062509] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM062509] Funding Source: NIH RePORTER
Growth of organisms and their constituent parts responds to both intrinsic and extrinsic cues during development: organisms of a given species generally grow at a predictable rate and to a specific body size, but individuals can modify this program during development in response to environmental conditions. Recent experiments, using gene knockouts and targeted overexpression, have revealed the central role of a signaling network controlled by the PI3K and TOR kinases in this regulation. These signaling molecules control growth by coordinately regulating a large number of cell biological processes. This review focuses on the cellular activities regulated by PI3K and TOR during development, and discusses how changes in different aspects of cellular metabolism may interact to regulate growth. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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