期刊
JAPANESE JOURNAL OF OPHTHALMOLOGY
卷 47, 期 6, 页码 548-550出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0021-5155(03)00141-2
关键词
Behcet's disease; endophthalmitis; granulocytes; interleukin-8
Background: Interleukin-8 (IL-8) is believed to be involved in the progression of intraocular inflammation. We sought the source of IL-8 in the enucleated eye of the present patient. Case: A 40-year-old Japanese man was diagnosed as having Behcet's disease. His vision deteriorated due to persistent uveitis and secondary glaucoma. His left eye had lens-induced endophthalmitis. Observations: The left eye had to be enucleated, and it was investigated by an immunohistochemical analysis using antibodies for CD la (dendritic cells), CD 3 (T cells), CD 68 (monocytes/macrophages), interferon-gamma, or IL-8. Fibrovascular tissue had formed on and beneath the lens where inflammatory cells had infiltrated. Most of the mononuclear inflammatory cells were T cells. A large number of macrophages were observed especially around the lens. Interferon-gamma-positive cells were scattered, while IL-8 was observed only in the accumulated granulocytes, but not in either mononuclear cells or macrophages. Conclusion: IL-8 is thus considered to play a role in the progression of intraocular inflammation, and granulocytes are thought to be a possible source of IL-8 in endophthalmitis. (C) 2003 Japanese Ophthalmological Society.
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