期刊
TRENDS IN NEUROSCIENCES
卷 26, 期 11, 页码 578-580出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2003.08.009
关键词
-
资金
- Telethon [E.0828] Funding Source: Medline
Neuromelanin accumulates in dopaminergic neurons during normal aging, and in Parkinson's disease, neurons with this pigment are those that selectively degenerate. Intraneuronal neuromelanin could play a protective role during its synthesis by preventing the toxic accumulation of cytosolic catechol derivatives and, in addition, by its ability to scavenge reactive metals, pesticides and other toxins to form stable adducts. However, dying neurons in Parkinson's disease that release neuromelanin might induce a vicious cycle of chronic neuroinflammation and neuronal loss.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据