期刊
INTERNATIONAL IMMUNOLOGY
卷 15, 期 12, 页码 1485-1494出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxg146
关键词
positive selection; signal transduction; thymocyte maturation; thymus; Wnt signaling
类别
资金
- NATIONAL INSTITUTE ON AGING [Z01AG000768, ZIAAG000768] Funding Source: NIH RePORTER
T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that beta-catenin, a central effector in the Wnt-TCF-1 signaling pathway, regulates late stages of T cell development. Specifically, transgenic expression of beta-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-beta-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.
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