期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 9, 期 6, 页码 439-445出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2012.30
关键词
germinal center kinases; immune regulation; signal transduction
类别
资金
- Ministry of Science and Technology of China [2010CB529700, 2012CB910204]
- National Natural Science Foundation of China [NSFC10979005, NSFC30970566]
- Science and Technology Commission of Shanghai Municipality [11JC14140000]
- NIH, NCI
- Abramson Family Research Institute
- BCRF
Germinal center kinases (GCKs) participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system. Cellular & Molecular Immunology (2012) 9, 439-445; doi:10.1038/cmi.2012.30; published online 10 September 2012
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