期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 31, 期 11, 页码 1299-1313出版社
SPRINGER
DOI: 10.1114/1.1630320
关键词
blood flow; cell adhesion; cell-to-cell communication; ligand-receptor interactions; sickle cell amemia; diabetes mellitus; malaria
资金
- NHLBI NIH HHS [HL18672, R01 HL50601] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL050601, R01HL018672, R37HL018672] Funding Source: NIH RePORTER
Abnormal interactions between red blood cells (RBCs) and vascular endothelial cells (ECs) are crucial factors in causing vascular pathology in several diseases, including vaso-occlusive crises in sickle cell anemia and the development of vascular complications in diabetes mellitus and malaria. A mechanistic understanding of the specific nature of RBC-EC interactions and ensuing functional consequences can provide insights into the pathophysiology of RBC-related vascular disorders and a rational basis for developing novel therapies. This review discusses in vitro experimental models that are commonly used for investigating RBC-EC interactions, and current knowledge of the molecular mechanisms of RBC-EC adhesion and EC functions modulated by RBCs. Because blood flow-induced mechanical forces and convective mass transfer play significant roles in regulating vascular events, it is necessary to develop advanced dynamic experimental models for elucidating RBC-EC interactions under well-controlled, physiologically relevant mechanical environments. (C) 2003 Biomedical Engineering Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据