期刊
PROSTATE
卷 57, 期 4, 页码 280-289出版社
WILEY-LISS
DOI: 10.1002/pros.10302
关键词
genetic susceptibility; cancer predisposition; familiar cancer; homogeneous population
资金
- NCI NIH HHS [U01 CA89600, CA-06927] Funding Source: Medline
- NHGRI NIH HHS [N01-HG-55389] Funding Source: Medline
- NIGMS NIH HHS [GM 08663] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [U01CA089600, P30CA006927] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [N01HG055389, Z01HG000107] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T34GM008663] Funding Source: NIH RePORTER
BACKGROUND. In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS. Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS. The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (0 = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS. The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
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