期刊
JOURNAL OF NEURAL TRANSMISSION
卷 110, 期 12, 页码 1401-1411出版社
SPRINGER WIEN
DOI: 10.1007/s00702-003-0061-3
关键词
dementia; depression; psychosis; schizophrenia; homocysteine
Homocysteinemia has been reported to be a risk factor for dementia, depression and also schizophrenia, the latter in a gender-specific manner. We have determined homocysteine in female inpatients suffering from various psychiatric diseases to further investigate a possible association between homocysteinemia and psychiatric disorders. Homocysteine was not elevated in schizophrenic females (mean, 11.6+/-5.8 mumol/l); in accordance with previous studies, homocysteinemia could be found frequently in dementia of different aetiology (mean, 17.2+/-6.7 mumol/l), but also to a slighter extent in depressive disorders (mean, 12.9+/-3.8 mumol/l), especially in elderly subjects. We thus suggest that homocysteinemia, at least in females, is an unspecific risk factor for organic brain disorders, but not endogenous psychoses.
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