期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 25, 期 12, 页码 1034-1041出版社
WILEY
DOI: 10.1002/hed.10317
关键词
chemoradiation; dropout; dysphagia; generalized linear models; head and neck
资金
- NATIONAL CANCER INSTITUTE [P01CA040007] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [P50DE011921] Funding Source: NIH RePORTER
- NCI NIH HHS [P01 CA40007] Funding Source: Medline
- NIDCR NIH HHS [P50 DE/CA11921] Funding Source: Medline
Background. Head and neck cancer patients treated with chemoradiation have difficulty eating a normal diet. This study was designed to characterize eating ability over 12 months after chemoradiation treatment. Analyses take patient dropout into account. Methods: Two hundred fifty-five patients with head and neck cancer treated with chemoradiation were followed for 12 months. Eating ability was analyzed using generalized linear model methods that accounted for non-ignorable dropout. Results. Eating ability was compromised immediately after treatment and improved over 12 months to near pretreatment levels. Ability to eat at most 50% of the diet orally did not return to baseline levels (p < .05). However, the percent of patients eating a normal diet did return to baseline levels. Accounting for dropout modified the results, but the pattern of significance was similar. Conclusions. Treatment of head and neck cancer with chemoradiation has a significant effect on eating ability, which improves after 12 months after treatment. (C) 2003 Wiley Periodicals, Inc.
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