期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 7, 期 2, 页码 83-88出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2009.111
关键词
semaphorin; immune regulation; immune cell trafficking; tumorigenesis; autoimmune diseases
类别
资金
- JSPS
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Ministry of Health, Labor, and Welfare
- National Institute of Biomedical Innovation
- Japan Science and Technology Agency
- Uehara Memorial Foundation
- Takeda Scientific Foundation
Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several members of semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of immune responses. These semaphorins regulate both immune cell interactions and immune cell trafficking during physiological and pathological immune responses. Here, we review the following two functional aspects of semaphorins and their receptors in immune responses: their functions in cell-cell interactions and their involvement in immune cell trafficking. Cellular & Molecular Immunology (2010) 7, 83-88; doi: 10.1038/cmi.2009.111; published online 1 February 2010
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