期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 7, 期 2, 页码 157-162出版社
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2009.117
关键词
CD4(+)CD25(+)Foxp3(+) T cells; CD4(+)CD44(+)/CD8(+)CD44(+) effector-memory T cells; low-dose total body irradiation; LTBI; tumor vaccine
类别
资金
- National Science Foundation of China [30872387, 60537030]
- National Fund for Talent Training in Basic Science [J0730860]
- National Basic Research Program [2010CB912603]
Low-dose total body irradiation(LTBI) is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4(+)CD25(+)Foxp3(+) regulatory T cells are markedly decreased in naive mice following treatment with LTBI. On the contrary, the CD4(+)CD44(+)/CD8(+)CD44(+) effector-memory T cells are greatly increased. Importantly, naive mice treated with dendritic cell-gp100 tumor vaccines under LTBI induced an enhancement of antigen-specific proliferation and cytotoxicity as well as interferon-gamma (IFN-gamma) secretion against F10 melanoma tumor challenge, compared to treatment with either the tumor vaccine or LTBI alone. Consequently, the treatment resulted in a reduced tumor burden and prolonged mouse survival. Our data demonstrate that LTBI's enhancement of antitumor immunity was mainly associated with selectively decreasing the proportion and number of T regulatory cells, implying the potential application of the combination of LTBI and a tumor vaccine in antitumor therapy. Cellular & Molecular Immunology (2010) 7, 157-162; doi: 10.1038/cmi.2009.117; published online 8 February 2010
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