期刊
CELLULAR & MOLECULAR IMMUNOLOGY
卷 5, 期 2, 页码 79-89出版社
CHINESE SOC IMMUNOLOGY
DOI: 10.1038/cmi.2008.10
关键词
IL-7 receptor; cytokine; signaling network; systems biology; modeling
类别
资金
- NATIONAL CANCER INSTITUTE [R01CA100875] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI069208, R01AI065824, R01AI040146] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM068762] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA100875-04, R01 CA100875-02, R01 CA100875-05, R01 CA100875, R01 CA100875-03, R01 CA100875-01A1, CA 100875] Funding Source: Medline
- NIAID NIH HHS [R01 AI069208, R01 AI040146-09, R01 AI069208-02, R01 AI065824, R01 AI069208-01, R01 AI040146-10, AI 69208, R01 AI069208-03, R01 AI040146, R01 AI040146-03, R01 AI065824-04, AI 06582, R01 AI040146-05, R01 AI040146-06A1, R01 AI040146-08, AI 40146, R01 AI040146-07, R01 AI040146-04, R01 AI040146-05S1] Funding Source: Medline
- NIGMS NIH HHS [P50 GM068762-060002, P50 GM068762] Funding Source: Medline
- PHS HHS [P50 068762] Funding Source: Medline
Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.
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